Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers
نویسندگان
چکیده
منابع مشابه
Integrins as Therapeutic Targets: Successes and Cancers
Integrins are transmembrane receptors that are central to the biology of many human pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with an emerging role as local activators of TGFβ, they influence cancer, fibrosis, thrombosis and inflammation. Their ligand binding and some regulatory sites are extracellular and sensitive to pharmacological interventi...
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چکیده ندارد.
15 صفحه اولSiglec functions of microglia.
Microglia are the resident immune cells of the central nervous system. They can sense intact or lesioned cells and then respond in an appropriate way. Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways. Most Siglecs contain an immunoreceptor tyrosine based inhibition motif and its signaling leads to the terminatio...
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ژورنال
عنوان ژورنال: Journal of the Formosan Medical Association
سال: 2021
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2019.10.019